As expected, AUDIT-C and AUDIT-P were highly genetically correlated (rg = 0.70, p = 4.1 × 10−70). AUDIT scores (AUDIT total score, AUDIT-C, and AUDIT-P) showed strong genetic correlations with alcohol consumption from two other studies (rg = 0.76–0.96, p < 2.3 × 10−9). Many of the genetic correlations with AUDIT-P were significantly different from the correlations with AUDIT-C (Supplementary Table 6). The AUDIT-C had a significantly stronger (p = 8.02 × 10−3) correlation with alcohol consumption (rg = 0.92, p = 7.0 × 10−164) than did AUDIT-P (rg = 0.76, p = 2.7 × 10−52). In contrast, AUDIT total and AUDIT-C scores were only modestly correlated with alcohol dependence (rg = 0.39 and 0.33 respectively, p < 8.2 × 10−5), whereas AUDIT-P showed a nominally stronger genetic correlation with alcohol dependence (rg = 0.63, p = 1.8 × 10−8; AUDIT-P vs AUDIT-C, p = 0.033; see Supplementary Table 6).
