Finally, we used MAGMA 51 to conduct a gene-wise BD GWAS and to test for enrichment of pathways curated from multiple sources (see Supplementary Note). We note that significance levels were assigned to genes by physical proximity of SNPs, and do not imply that significant genes are causal for BD. Genic association results included 154 Bonferroni significant genes (MAGMA pJOINT < 2.8×10−6), including 82 genes in 20 genome-wide significant loci, and 73 genes in 27 additional loci that did not reach genome-wide significance (Supplementary Table 17). Nine related pathways were significantly enriched for genes with BD associations (p < 7.0×10−5, FDR < 0.05), including abnormal motor coordination/balance pathways (from mice), regulation of insulin secretion, and endocannabinoid signaling (Supplementary Table 18, Supplementary Figure 7).
