(LOD = 2.61) and 9q34 (LOD = 2.57). These areas of the genome were not identified in the current linkage scan for Cannabis dependence II/B, however, a region on chromosome 3 was previously identified in a genome-wide linkage analysis for loci associated with the syndromic diagnoses of childhood conduct disorder (CD), ASPD, and the combined phenotype ASPD/CD in this Native American community. Agrawal and colleagues (2008) conducted a linkage scan in a sample from the COGA study for six DSM-IV cannabis dependence criteria considered as a continuous variable (0–6) and found a maximum LOD score of 1.9 at 95 cM on chromosome 14. A “region of interest” on chromosome 14 at 122 cM was also found for the type B/II cannabis subtype in the present study. This region on chromosome 14 was also identified previously in a genome-wide linkage analysis for ASPD/CD in this Native American community (Ehlers et al., 2008).
