A number of methods can be used to specify genes and genomic regions. For example, the query ‘ENTREZ_GENE_QUERY = Dopamine and Receptor,1.0’retrieves all genes from the Entrez Gene database (http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene) that match the terms ‘dopamine’ and ‘receptor’ and assigns them all a prioritization score of 1.0. SNPs from an entire region can be prioritized with a query of the form ‘REGION = Chr15:76600000.76700000, 1.25′, which would add a score of 1.25 to all SNPs in this 100 Kb region on chromosome 15 via the ‘User Region’ node of the GIN model. More information on the different kinds of queries is provided in the ‘User’s Guide’ (https://spot.cgsmd.isi.edu/doc/user_guide.pdf).
