Major depression data were drawn from the full cohort (PGC MDD: 135,458 cases, 344,901 controls) from (15). This included data from 23andMe (20), access to which requires a Data Transfer Agreement; consequently, the data analysed here differ from the summary statistics available at the link above. Data for bipolar disorder were drawn from the discovery analysis previously reported (PGC BD: 20,352 cases, 31,358 controls), not including replication results (16).