Our primary aim was to combine analyses of bipolar disorder and major depression to examine the shared and distinct genetics of these disorders. Summary statistics were derived from participants of Western European ancestries. Full descriptions of each study and their composite cohorts are provided in each paper (15, 16, 19). Brief descriptions are provided in the Supplementary Methods. Except where otherwise specified, summary statistics are available (or will be made available) at https://www.med.unc.edu/pgc/results-and-downloads.