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Chunk #13 — Discussion

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GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.
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use with household income and fluid intelligence using UK-Biobank data. Within Caucasian participants of UK-Biobank (N=438,870), categorically rated household income was higher among lifetime cannabis users compared to non-users (χ2[4]=2243, p=2.2e-16). Cannabis users also scored higher on fluid intelligence (t[50,856]=25.13, p<2e-16). These findings are in agreement with observations by Patrick et al.47, who showed that cannabis use is associated with higher childhood family social economic status (SES) in a survey of US families. Possibly, environments more often experienced by those with higher SES backgrounds, such as universities, increase accessibility to cannabis, explaining how a positive correlation between lifetime cannabis use and educational attainment in our study could arise.