To evaluate gene sets related to antidepressants, gene-sets were extracted from the Drug-Gene Interaction database (DGIdb v.2.0)105 and the Psychoactive Drug Screening Program Ki DB106 downloaded in June 2016. The association of 3,885 drug gene-sets with major depression was estimated using MAGMA (v1.6). The drug gene-sets were ordered by p-value, and the Wilcoxon-Mann-Whitney test was used to assess whether the 42 antidepressant gene-sets in the dataset (ATC code N06A in the Anatomical Therapeutic Chemical Classification System) had a higher ranking than expected by chance.
