same SNPs interacted significantly on risk for schizophrenia in the combined, three-sample dataset (P = 0.0017). Individuals who were minor allele carriers at both rs10089 in SLC12A2 and rs1000731 in DISC1 were positively associated with risk for schizophrenia compared with all other genotypes (OR = 1.42, P = 0.001, LRT P = 0.0037; Table S2). None of these SNPs showed main association effects with schizophrenia on their own (Table S2). These results suggest that DISC1 and NKCC1 may interact to affect clinical risk for the development of schizophrenia.
