The DISC1 SNP maps close to the translocation breakpoint in the Scottish family (Millar et al., 2000) and may affect or be in linkage disequilibrium with SNPs that affect splicing of short DISC1 transcripts that are upregulated in postmortem brains from patients with schizophrenia (Nakata et al., 2009). The SNP in NKCC1 is in the 3’UTR where microRNA regulation of gene function occurs and it is predicted in silico to affect microRNA mechanisms (Friedman et al., 2009). In an effort to uncover other evidence that these SNPs proxy variants impact on the function of these two genes, we interrogated a public database for genetic regulation of transcript expression in human brains, which includes SNP genotype statistical associations with the expression of specific exons (Heinzen et al., 2008). Interestingly, rs1000731 predicts the expression of a probe of exon 3 in the DISC1 gene (P < 0.006), and rs10089 predicts the expression of an expressed sequence in the 5’ region of the NKCC1 gene (P < 0.02). Thus, each of these SNPs, which interact to affect risk for schizophrenia, is associated with
