Glioma is one of the most common and lethal primary malignant tumors of the brain, and it is classified into four categories: low-grade glioma (including categories I and II) and high-grade glioma (including categories III and IV), according to World Health Organization grading criteria.1,2 High-grade glioma cells easily infiltrate the extracellular matrix of human brain cells, which is a major challenge for achieving a radical cure, especially using traditional methods such as surgery, radiotherapy, and chemotherapy.3,4 Therefore, identifying tumor biomarkers and developing molecular targeted therapies for glioma have become important research goals for improving the prognosis of patients with glioma. In the present study, we focused on the expression of long non-coding RNAs (lncRNAs) and potential interacting factors in glioma to highlight new potential targets for treatment or diagnosis, as well as to gain new insight into the mechanisms of glioma malignant transformation.
