The important roles of RNAs and their regulatory mechanisms in physiological and pathological processes, including tumorigenesis, are increasingly being revealed and recognized as candidate targets for biomarkers and cancer treatments. lncRNAs are a class of endogenous RNA molecules with transcripts longer than 200 nt and limited protein-coding potential.5 Several lncRNAs have been identified to act as either oncogenes or tumor suppressors, regulating the biological process of the tumor cell cycle and tumorigenesis.6 Accumulating evidence indicates that RNA-binding proteins (RBPs) directly bind to and stabilize lncRNAs to regulate tumor biological processes.7 For instance, HuR was found to stabilize lncRNA HOTAIR to promote its expression in head and neck squamous cell carcinoma.8 HuR also functions as a tumor facilitator in ovarian cancer by enhancing the stability of lncRNA NEAT1 to promote malignant progression.9 The lncRNA CRNDE could be stabilized by hnRNPUL2, thereby accelerating cell proliferation and migration in colorectal carcinoma.10
