The dynamic complex of RNAs and RBPs mediates virtually all stages of the RNA life cycle, and dysfunction in RBPs can cause changes to the transcriptome and proteome of the cell, leading to tumor growth and aberrant biological behaviors.11,12 TATA-box binding protein associated factor 15 (TAF15), a member of the FET family, plays an important role in regulating mRNA transcription, RNA splicing, and transportation, and it shows a high translocation rate in certain malignant tumors such as liposarcoma and Ewing’s sarcoma.13, 14, 15 TAF15 was also shown to promote the proliferation of human neuroblastoma cells via altering gene expression through a microRNA-involved pathway.16 Therefore, we examined the expression of TAF15 in glioma tissues and cells and used microarray analysis to identify differentially expressed lncRNAs in TAF15-overexpressed glioma cells. Among the candidates, the downregulated long intergenic non-protein coding RNA 665 (LINC00665) in glioma sparked our interest. Studies suggest that LINC00665 contributes to a high risk of oral premalignant lesions.17
