STAU1-mediated mRNA decay (SMD) is a common mRNA degradation process in mammalian cells, which regulates numerous biological processes, including myogenesis, keratinocyte-mediated wound healing, and adipogenesis.18,19 This pathway involves STAU1, a double-stranded RBP, that recognizes the STAU1-binding site (SBS) as a complementary double-stranded RNA structure formed either by intramolecular or intermolecular base pairing of the target mRNA 3′ untranslated region (UTR) and lncRNA.20 Upon binding of STAU1 to the SBS, the complex recruits UPF1 to the 3′ UTR of the target mRNA, thereby inducing mRNA degradation and shortening the half-life of target mRNA.21 Therefore, we examined the potential influence of LINC00665 downregulation in glioma with STAU1 expression as a potential mechanism by which RNA dysfunction mediates malignancy.
