Metal regulatory transcription factor 1 (MTF1) is a highly conserved Cys2His2 zinc finger protein with six zinc finger domains, and it also plays a key role in transcriptional regulation by binding to DNA.22,23 MTF1 can be activated by growth factors, redox stress, and cytokines, thus playing a crucial role in both embryogenesis and hematopoiesis. Moreover, MTF1 has been shown to be overexpressed in breast cancer, cervical cancer, colorectal cancer, and lung cancer, suggesting a potential role in malignancy.22,24 We further focused on the potential role of the YY2 transcription factor (YY2) in glioma, as a multi-functional transcription factor of the YY family. As a paralog of YY1, YY2 has different modes of regulation on multiple tissues and cells, and it participates in the self-renewal and differentiation of mouse embryonic stem cells into cardiovascular lineages.25,26
