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Chunk #18 — Method — Statistical analysis

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Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction.
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Models for dichotomous outcomes were performed as relative risk regressions using a quasi-likelihood approach in SAS PROC GENMOD (SAS Institute, 2008). The predicted outcome was p (the probability of being a drinker) while the residual variance was allowed to be heteroscedastic, estimated as p/(1 − p). Predicted outcomes were constrained to lie in the interval (0,1).