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Chunk #19 — Results — Developmental effects of two forms of genetic risk

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Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction.
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The relationship between genetic risk for AUDs (GR-AUD) and genetic risk for externalizing disorders (GR-ExtD) and maximal alcohol consumption over development are depicted in Fig. 1. For GR-ExtD, the regression coefficient begins at +0.10 at ages 12–14, rises rapidly to +0.21 at ages 15–17, and then declines slowly to +0.15 at ages 26–33. The pattern is somewhat different for GR-AUD, which also starts at a relatively low value at ages 12–14 (+0.09) and then rises first quickly and then more slowly (aside from an anomalous dip at ages 26–29), reaching a peak value of +0.20 at ages 30–33.