In order to quantify the magnitude of intra-European differences in LD Score, we estimated LD Scores using each of the 1000 Genomes European subpopulations: Utah Residents with Northern and Western European Ancestry (CEU), British in England and Scotland (GBR), Toscani in Italia (TSI) and Finnish in Finland (FIN). The LD Scores from the four subpopulations were all highly correlated but the mean LD Score was not constant across populations. The mean LD Scores (MAF > 1%) were EUR, 110; CEU, 109; GBR, 104; FIN, 117; TSI, 102. The observation that the mean LD Score in the Finnish (FIN) population was elevated is consistent with a recent bottleneck in the genetic history of Finland40, and the observation that the mean LD Score in the Southern European TSI population is lower is consistent with reports that Southern European populations have gone through less severe bottlenecks than Northern European populations.
