paperKB
coga / coga-kb
Help
Sign in

Chunk #23 — ONLINE METHODS — Estimation of LD Score

Source
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.
Embedded
yes

Text

We estimated LD Score standard error via a delete-one jackknife over the 378 phased individuals in the 1000 Genomes European reference panel. We found that the LD Score standard error was positively correlated with MAF and with LD Score itself. Jackknife estimates of LD Score standard error became extremely large for variants with MAF < 1%, so we excluded variants with 1000 Genomes European sample MAF < 1% from all LD Score regressions.