EAGLE includes 2101 verified, incident, primary lung cancer cases of any histologic type, with the exception of carcinoids, and 2120 healthy population-based controls. Participants are both male and female, born in Italy, of Italian nationality, and with official residence in the 216 selected municipalities, at ages between 35 and 79 years old at diagnosis (cases) or enrollment for interview (controls) that signed an informed consent form to participate in the study. The study was approved by the Institutional Review Board (IRB) of each participating hospital and university in Italy and by the National Cancer Institute, Bethesda, MD.
