EAGLE's study size is powered to detect small increases in risk for factors with moderate frequency; for example the power is at least 80% to detect an association between a given genotype and lung cancer risk with an OR of 1.4 for at-risk genotype frequency between 10% and 90%. Under a multiplicative gene-environment interaction model, the study is large enough to reject at a 0.05-level with 80 percent power an interaction of 0.5 between the highest smoking category relative to the non-smoking category when the at-risk genotype frequency is > 13%, and of 0.2, if the at-risk genotype frequency is 5% or higher and the distributions of smoking and the gene are independent [7].
