greater under alcohol than under placebo. Of the 7 subjects in the smaller analyses, only 2 had a pronounced right lateral orbital [AO > ApCO] response under placebo, while four had a pronounced effect under alcohol (the remaining subject had a nonsignificantly greater response under alcohol). Finally, compared to our prior study (Kareken et al., 2004), we did not find NAc activation without exposure to alcohol. The reasons for this remain unclear, although one important difference between the two studies is that the priorsample of hazardous drinkers was composed uniquely of individuals with a family history of alcoholism (e.g., see Murphy et al., 2002).
