There remain important limitations to consider in this study, particularly in making inferences about activity in the NAc and in medial/orbitofrontal areas. Specifically, not all subjects had available imaging data for both the alcohol and placebo sessions, with only 7 subjects having both alcohol and placebo session data. Analyses in this smaller data set also have more limited power to detect effects. While this direct paired analysis principally showed significant differences between alcohol and placebo sessions in the posterior cingulate/retrosplenial area, medial-frontal cortex continued to show significant trends suggesting that AO evoked more activity under alcohol than under placebo, mainly in contrast to ApCO (607 voxels at [−6, 34, 20] at p < 0.05). Orbitofrontal cortex also showed a small cluster of 27 voxels ([24, 32,−22] at p < 0.05) in which activity from the [AO > ApCO] comparison was greater under alcohol than under placebo. Of the 7 subjects in the smaller analyses, only 2 had a pronounced right lateral orbital [AO > ApCO] response under placebo, while four had a pronounced effect under alcohol (the remaining subject had
