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Chunk #20 — Results — Genes Associated With PD Risk Through Changes in Splicing

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Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.
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1). We then assessed the eQTL P values of the top SNV suggested by Coloc for the associated exon and the gene as a whole, showing that, for these associations, the gene-level P value is not significant, while the exon-level P value is significant. These genes are summarized in Table 2. Full details for all splicing events that showed strong evidence for colocalization in Braineac, and of all genes significant at FDR 0.05 level in the TWAS analysis are found in eTable 4 in Supplement 5 and eTable 5 in Supplement 6.