To assess splicing changes, we used the Braineac data set, which had exon-level eQTL data. A total of 25 genes in Braineac had strong evidence for colocalization for at least 1 exon in at least 1 brain region. For 15 genes there was evidence suggesting that the association is owing to an exon-level splicing event (exon PPH4 ≥ 0.75) rather than a gene-level expression effect (gene PPH3>PPH4). In the TWAS analysis, 129 genes had evidence for splicing in at least 1 isoform at FDR 0.05 level. Of these, 40 were within 1 Mb of a PD-significant SNV. Six genes with a putative splicing effect in the Coloc analysis showed a significant splicing effect in the TWAS analysis (ZRANB3 [OMIM 615655], PCGF3 [OMIM 617543], NEK1 [OMIM 604588], NUPL2 [NCBI 11097], GALC [OMIM 606890], and CTSB [OMIM 116810]) (eFigure 1B in Supplement 1). We then assessed the eQTL P values of the top SNV suggested by Coloc for the associated exon and the gene as a whole, showing that, for these associations, the gene-level P value is not significant, while the exon-level
