analysis of candidate SNPs in Asian populations identified SNP rs1078985 as a potential breast cancer susceptibility variant31. This variant, however, was uncorrelated with rs12493607 in Europeans and showed no evidence of association in our study (P = 0.33 in the iCOGS stage). SNP rs7904519 lies in intron 4 of TCF7L2. A previous candidate gene study found weak evidence for an association between a correlated SNP, rs12255372, associated with type 2 diabetes (r2 = 0.37 with rs7904519), and familial breast cancer (P = 0.04)32.
