HiPSC model generation is a two-step process. The process begins by taking a somatic cell (any cell that isn’t a sex cell) and reversing it (known as reverse differentiating and/or reprogramming) back to its embryonic stem cell-like state, known as the hiPSC state. The hiPSC then allows the experimenter to generate, through the differentiation process, the somatic cells required to model the disorder of interest (in the context of neurodevelopmental disorders this would likely be some brain region, neuronal network, or neuronal subtype).
