In summary, hiPSCs allow us to replicate the disease-altered trajectory of early brain development and examine when phenotypic and molecular abnormalities arise in these diseased brains. Furthermore, hiPSCs retain the patient’s unique genetic signature and thus can recapitulate the patient’s idiosyncratic neural development. In future, hiPSC-based studies, imaging studies, and perhaps other patient-based observational studies could be integrated in such a way that various technologies can inform each other22,24–26.
