Similarly, implementation of genome-scale deep sequencing technologies with hiPSC model systems has increased the potential of these systems. These techniques can reveal the consequences of gene mutations on the entire cellular transcriptome, and, in turn, how changes in transcriptomics translate into cellular phenotypes. Genome engineering technologies should also help to determine which of the myriad developmental alterations are crucial for a given cellular and molecular phenotype. Cellular and molecular consequences of mutations can be explored in animal models and cultured human cell lines, but hiPSC-derived modeling provides information that is immediately applicable to humans because hiPSCs have a specific human genetic background and, given sufficient sample size, can reveal how inter-individual genetic variations influence phenotypes.
