We then examined the relationship between offspring OCD+ADHD and parental diagnoses. Parental OCD+ADHD, in particular, maternal OCD+ADHD, was independently associated with offspring OCD+ADHD (OR=5.45, p<0.0001 for maternal; OR=3.0, p=0.009 for paternal; overall model: X2=30.8, p<0.00001). This model was very similar to the model that incorporated parental diagnoses of OCD and ADHD independently. Parental triple diagnoses (i.e., TS+OCD+ADHD) showed a similar pattern, with even stronger associations. Maternal TS+OCD+ADHD increased the risk of offspring OCD+ADHD by over 6-fold (OR=6.6, p<0.0001), while paternal TS+OCD+ADHD increased the risk of offspring OCD+ADHD by approximately 3-fold (OR=2.8, p=0.019; overall model: X2=21.9, p<0.00001). Note that that vast majority of the offspring had TS diagnoses (89%), while an additional 4% had CMVT, so that offspring OCD+ADHD was essentially equivalent to TS+OCD+ADHD.
