The second example concerns the TP63 gene. There are two well-studied isoforms for this gene, TA-alpha (43) and deltaN (44). They are generated from different translation start sites and generate different N-terminals (Figure 3A). However, rather than elect one of these two, APPRIS gives the best score to variant TP63-013, a 582-amino acid protein. Although this result might be surprising at first glance, it is perfectly logical.
