The Catalog has been available as a tab delimited download for 10 years and this requires users to parse and iterate over each biweekly data release for integration of analysis. We have therefore deployed a new RESTful API (www.ebi.ac.uk/gwas/rest/api) that provides programmatic access to the GWAS Catalog data (excluding SS, which are accessible from a dedicated API). Requests are submitted as HTTP and returned in JSON to support additional query granularity requested by programmatic users, for example, ancestry information and author's ORCIDs. Example scripts are available illustrating common queries, for example, retrieval of associations for a trait or variant (www.ebi.ac.uk/gwas/labs/rest/docs/sample-scripts).