The GeneNetwork phenome database contains a large number of neuroanatomical morphometric measurements. Many of these [60] were strongly associated with ErGeN1 in its entirety (i.e., all trans-bands), including ventral hippocampus volume, overall brain weight, dorsal thalamus volume and amygdala basolateral complex volume [54]. This network was also highly correlated with the B max for naloxone binding [61], a μ-opioid receptor antagonist that is an approved treatment for alcoholism. Whereas only a subset of ErGeN1's trans-bands were correlated with morphine metabolism rate [62]; the same two trans-bands also correlated with ethanol acceptance in a two-bottle choice test [63].
