This analysis also revealed ErGeN'3s to be important potential mediators of phenotypic responses to several drugs of abuse. As a whole, ErGeN1 impacts both baseline locomotor activity [64] and habituation [65] in novel open field tests, but the effect of cocaine on these phenotypes was primarily correlated with ErGeN1's Chr 7 trans-band. Interestingly, non-locomotor based responses to cocaine were associated exclusively with ErGeN3, including measurements of stereotypic repeated movements [66], [65] and conditioned place preference for the drug (Phillips et al., unpublished). Given the importance of dopamine levels in activating these behaviors, particularly stereotypy, we expected to find a strong connection between ErGeN1's Chr 7 trans-band and the dopamine binding phenotypes included in the GeneNetwork database. Instead, we observed that ErGeN7's solitary trans-band on Chr 19 to be the primary correlate of these measurements, which included Drd1 & Drd2 binding density in the dorsal striatum and NAc [65].
