Along with ErGeN1, ErGeN3 was related to Naloxone B max concentration but also showed strong correlations with morphine induced locomotor activation and naloxone induced morphine withdrawal (Phillips et al. unpublished). These morphine phenotypes were also connected to ErGeN10. This overlap is perhaps not surprising given the strong association between many genes within ErGeN3 and ErGeN10 (Figure 3c), as well as the shared trans-band support interval on Chr 11. However, one distinction between ErGeN3 and ErGeN10 was the clustered connections of numerous ethanol relevant phenotypes to ErGeN10. While ErGeN3 correlated with ethanol metabolism rate [67] and blood glucose levels following ethanol treatment [68], ErGeN10 appears more related to ethanol behavioral phenotypes, including ethanol induced locomotor activation [63], anxiolysis (Cook et al., unpublished) and sensitization [69].
