the chromosome 4 SNPs were also available in the German sample. Results for four SNPs (rs17028615, rs904092, rs1789882 and rs1693457) that were below the GWS threshold in the GWAS sample became GWS in the meta-analysis of all data sets. An additional SNP, rs4699741, nearly reached this threshold (P = 6.11 × 10−8). Further, an intergenic SNP on chromosome 2 between MTIF2 and PRORSD1P was significant after pooling results from the case–control analysis of all AA and EA data sets (P = 1.17 × 10−10), although the effect was evident primarily in EAs. Because information required for the ordinal trait analyses was unavailable in the German sample, it is unclear whether this finding would be stronger in a quantitative trait model of AD.
