Sixteen of the chromosome 4 SNPs in the GWAS sample that were GWS in the ordinal trait analyses were genotyped in our identically assessed replication sample. All were at least nominally significant, and the percentage of significant FDR q-values was greater than would be expected by chance in each model and population (AA case-control = 31%, AA ordinal = 39%, EA case-control = 17%, EA ordinal = 62%, German sample = 67%). Six SNPs were significant at P < 0.001, including ADH1B SNPs rs2066702 (P = 3.20 × 10−5) in AAs and rs1229984 (P = 1.14 × 10−6) in EAs (Table 3a). The results became more significant in the meta-analysis of the discovery and replication samples. In the case–control analysis, 13 of the SNPs were nominally significant in at least one replication sample (Table 3b). Genotype data for five of the chromosome 4 SNPs were also available in the German sample. Results for four SNPs (rs17028615, rs904092, rs1789882 and rs1693457) that were below the GWS threshold in the GWAS sample became GWS in the meta-analysis of all data sets. An
