Chunk #26 — Adenosine, Receptors and Functions in the CNS — Adenosine A2AR and Functions in the CNS — [18F] PET radio ligands of adenosine A2AR

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Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications.

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Few 18F PET radioligand derivatives of potent and selective A2AR antagonist SCH442416 were developed for imaging of the A2ARs. These PET ligands include [18F]MRS5425 ([18F]-FESCH),129,130 [18F]-FPSCH,130 and [18F]MNI-444131 as shown in Figure 5. The A2AR-mediated uptake of [18F]MRS5425 was higher in the striatum of the 6-OHDA lesion-induced rats compared to that of the normal rats, making [18F]MRS5425 a suitable PET radiotracer for imaging of PD patients.129