A fluoropropyl analog [18F]-FPSCH was also developed and studied for mapping of the A2A receptors expression in rat brain.130 Both [18F]-FESCH and [18F]-FPSCH showed similar striatum/cerebellum ratios post injection as well as reversible binding in the brains of rat.130 However, dynamic PET imaging for 60 minutes, under baseline and blocking conditions, demonstrated [18F]MRS5425 ([18F]-FESCH) to be the most suitable 18F PET radioligand for quantifying A2A receptor expression in rat brain.130
