sizes of these non-zero variants (i.e. “discoverability”’). 2) the variance estimates obtained in the univariate analysis were applied in the bivariate model (i.e. depression vs. each of the additional traits) to obtain four estimates representing (i) zero-effect SNPs in both traits; (ii) SNPs with a specific non-zero effect on trait 1; (iii) SNPs with a specific non-zero effect on trait 2; and (iv) SNPs with a non-zero effect on both traits. Estimates of polygenic overlap and genetic correlation between pairs of traits were obtained by combining these four components.
