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Chunk #14 — Methods — Type 2 diabetes case ascertainment and verification

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Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study.
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To increase the specificity of the case definition for centres other than those from Denmark and Sweden, we sought further evidence for all cases with information on incident type 2 diabetes from fewer than 2 independent sources at a minimum, including individual medical records review in some centres. Follow-up was censored at the date of diagnosis, the 31st of December 2007 or the date of death, whichever occurred first. In total, 12,403 verified incident cases were identified; there were 471 cases in the first year of follow-up and 587 in the second year. Sample size calculations are included in the online appendix (online appendix; figure SF1).