Chunk #73 — Methods — Parkinson’s disease rare variant enrichments

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.

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We searched the literature for genes associated with Parkinsonism on the basis of rare and familial mutations. We found 66 genes (listed in Table S12). We used linear regression to test whether the z-scaled specificity metric (per cell type) of the 66 genes were greater than 0 in the different cell types.