Chunk #72 — Methods — GO term enrichment

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.

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We tested whether genes that were highly specific to a trait-associated cell type (top 20% in a given cell type) AND highly associated with the genetics of the traits (top 10% MAGMA gene-level genetic association) were enriched in biological functions using the topGO R package 97. As background, we used genes that were highly specific to the cell type (top 20%) OR highly associated with the trait (top 10% MAGMA gene-level genetic association).