We further investigated the association of these five SNPs separately in 2,111 community nondiabetic, 1,516 T2DM-ESRD, and 1,362 T2DM subjects from cohorts 1 to 6 (Table 3). The effect sizes ranged from 0.102 to 0.181, 0.068 to 0.228, and 0.063 to 0.089 s.d. units, respectively, for the three groups. Although the effect sizes and association signals tended to be weaker in the T2DM group as compared to the nondiabetic or T2DM-ESRD groups, there were no significant heterogeneity of effect sizes among the three groups (Pheterogeneity >0.05). For the T2DM-ESRD group, additional adjustment for duration of ESRD revealed similar association results for the 60 tested SNPs (slope = 0.948, intercept = 0.197 by linear regression of –log P values for ESRD duration adjustment analysis on the–log P values for the analysis without ESRD duration adjustment).
