When we considered community nondiabetic subjects only, the effect sizes were comparable while the significance of associations were weaker than that in all combined samples due to reduced sample size (Supplementary Table S2 online). Of note, the strongest association was observed for rs268972 (β = 0.131 s.d. unit, P = 0.0002) and four of the five SNPs with suggestive association from meta-analysis of all combined samples (Table 2) were among the top 10 hits in the nondiabetic subjects.
