We performed a high-density GWAS on BMI to examine the genetic determinants of adiposity in African Americans. Meta-analysis of two GWAS and four replication cohorts revealed five SNPs (rs6794092, rs2033195, rs815611, rs6088887, and rs268972) at four loci showing suggestive association to BMI (2.4 × 10−6 < P < 2.5 × 10−5) (Table 2). Although no signals reached genome-wide significance (P < 5 × 10−8) potentially due to modest sample size and power at the respective α level, the consistent direction of associations in all six cohorts and nominal association in both GWAS and replication stages in the former four SNPs implicates them in the modulation of BMI levels.
