Following our preregistered analysis plan (https://doi.org/10.17605/OSF.IO/XKV36), we collated summary statistics from GWAS on externalizing-related traits (Supplementary Information section 1). For an exhaustive description of the phenotype selection procedure and GWAS protocol, see Supplementary Information section 2. All phenotypes considered for inclusion are listed in Supplementary Table 1. We first applied quality control (Supplementary Table 2) and excluded summary statistics based on power considerations (i.e., hLD Score2 < 0.05, or mean χ2 < 1.05)12. After applying these filters, 11 externalizing phenotypes remained, with sample sizes >50,000 (N = 53,293–1,251,809) (Supplementary Table 3). All samples were of European ancestry. The following seven phenotypes made it to the final multivariate model specification (Table 1 & Supplementary Table 4): (1) attention-deficit/hyperactivity disorder (ADHD)13, (2) problematic alcohol use (ALCP; a meta-analysis of alcohol dependence and AUDIT-P)14,15, (3) lifetime cannabis use (CANN)16, (4) reverse-coded age at first sexual intercourse (FSEX)17, (5) number of sexual partners (NSEX)17, (6) general risk tolerance (RISK)17, and (7) lifetime smoking initiation (SMOK)18.
