Ong and Mackie, using an N-terminal CB1 antibody, provided a description of CB1 receptor distribution within the primate brain (Macaca fascicularis)(Ong and Mackie, 1999). Their studies also reported that the amygdala was densely labeled for the CB1 receptor. Within the BLA, both putative pyramidal projection and non-projection neurons were labeled. EM studies revealed large, CB1-ir cell bodies with features of pyramidal projection neurons, as well as labeled smaller neurons with features of GABAergic interneurons. Many densely labeled dendrites were observed in the neuropil of the LA, which formed symmetric contacts with unlabeled axon terminals. In addition, occasionally labeled axon terminals forming asymmetric synapses were also observed (Ong and Mackie, 1999).
