Eggan and Lewis utilized C-terminal antibodies to explore the distribution of CB1 receptors within the amygdala of this species as well (Eggan and Lewis, 2007). Their findings were in qualitative agreement with those of Ong and Mackie as they observed a dense meshwork of CB1-ir varicose axons surrounding unstained cell bodies within the BLA; although some differences in the intensity of staining was seen within various subregions of the BLA. No CB1-ir axons were observed within the centromedial nuclei (CeA and MeA). However, light staining above that of the white matter was observed within these nuclei, although this labeling was noted to be morphologically indistinct (Eggan and Lewis, 2007). Though CB1 receptor expression within the amygdala may shed light onto its potential modulatory mechanisms, exploring the expression of the enzymes that are integral to eCB metabolism may further unveil the role of eCB signaling within the amygdala.
