Samples are described in detail in the supplementary methods section (Text S1). The studied 3,112 individuals representing a total of 19 cohorts (Czech Republic samples were used as one in all analyses except from the inter-population structure analyses) samples from 16 countries: Austria (Vienna), Bulgaria (entire country), Czech Republic (Prague, Moravia and Silesia), Estonia (entire country), Finland (Helsinki, and a young internal subisolate of Kuusamo), France (Paris), Germany (Schleswig-Holstein, Augsburg region), Hungary (entire country), Italy (Borbera Valley, Region of Apulia), Latvia (Riga), Lithuania (entire country), Poland (West-Pomerania), Russia (Andreapol district of the Tver region), Spain (entire country), Sweden (Stockholm) and Switzerland (Geneva) (Table 1).